Specifications
- Antibody type:Primary
- Antigen name:X-box binding protein 1
- Antigen symbol:XBP1
- Clonality:Monoclonal
- Clone:9B7E5
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Format:Purified Antibody
- Form:Liquid
- Gene ID:7494
- Antigen synonyms:XBP-1 Antibody [9B7E5] : XBP2, TREB5, XBP-1
- Storage temperature:XBP-1 monoclonal antibody can be stored at -20˚C, stable for one year.
- Concentration:1 mg/mL
- Shipping temperature:4°C
- Immunogen:Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.
- Purification:XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Size:100 μg
- Pk:100 µG
Specifications
About this item
XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
XBP-1 antibody can be used for the detection of XBP-1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 4 μg/mL.
Type: Primary
Antigen: XBP1
Clonality: Monoclonal
Clone: 9B7E5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human, Mouse, Rat