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Rat IgG2a Fc Isotype Control
Rat IgG2a Fc Isotype Control
Catalog # PRSI92-687
Supplier:  ProSci Inc.
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Rat IgG2a Fc Isotype Control
Catalog # PRSI92-687
Supplier:  ProSci Inc.

Specifications

  • Antibody type:
    Control
  • Host:
    Rat
  • Isotype:
    IgG2a
  • Reactivity:
  • Environmentally Preferable:
  • Form:
    Lyophilized
  • Antigen synonyms:
    Ig gamma-2A chain C region, Igg-2a|Igg-2a
  • Antibody fragment:
    Fc
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Storage buffer:
    Lyophilized from a 0.2 um filtered solution of 20mM Tris, pH 8.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Molecular weight:
    35.2 kD
  • Storage temperature:
    Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.
  • Size:
    0.05 mg
  • Pk:
    50 µG

Specifications

About this item

Immunoglobulin G (IgG) is a type of antibody composed of four peptide chains—two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers.There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum. The IgG2a isotype was able to interact very efficiently with FcgammaR, and share approximately 64-78% amino acid sequence identity with IgG1 and IgG2b in the heavy chain constant region domains, CH1, CH2 and CH3, which cause the diffrence in the interaction with complement, NK and mast cells, induction or inhibition by specific cytokines, and ability to cross the placenta.