Anti-CD22 Mouse Monoclonal Antibody (CF640R) [clone: Myg13]

Recognizes a protein of 130-140 kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD . It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

Type: Primary
Antigen: CD22
Clonality: Monoclonal
Clone: Myg13
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat

Catalog No:
BNC400974-500
BNC400974-100

Antigen symbol:
CD22
CD22

Antigen synonyms:
Sialic acid-binding Ig-like lectin 2 (Siglec-2)|Lyb8|B-cell receptor CD22|B-lymphocyte cell adhesion molecule (BL-CAM)|CD22|SIGLEC2|Lectin 2|T-cell surface antigen Leu-14
Sialic acid-binding Ig-like lectin 2 (Siglec-2)|Lyb8|B-cell receptor CD22|B-lymphocyte cell adhesion molecule (BL-CAM)|CD22|SIGLEC2|Lectin 2|T-cell surface antigen Leu-14