About this item
Recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Type: Primary
Antigen: BCL6
Clonality: Monoclonal
Clone: BCL6/850
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
Specifications
- Catalog No:
- BNC880850-100
- BNC880850-500
- Antigen symbol:
- BCL6
- BCL6
- Antigen name:
- bcl-6
- bcl-6
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone BCL6/850
- Clone BCL6/850
- Reactivity:
- Human, Mouse
- Human, Mouse
- Host:
- Mouse
- Mouse
- Gene ID:
- 478588
- 478588
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Chemicals
Supplier: HEATHROW
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: KIMBERLY CLARK
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: Merck
Supplier: VWR Collection
Supplier: VWR Collection