About this item
This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Type: Primary
Antigen: KRT10
Clonality: Monoclonal
Clone: KRT10/844
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
Specifications
- Catalog No:
- BNC680844-500
- BNC680844-100
- Antigen symbol:
- KRT10
- KRT10
- Antigen name:
- Cytokeratin 10
- Cytokeratin 10
- Antigen synonyms:
- Keratin Type I Cytoskeletal 10|EHK|BIE|BCIE|KRT10
- Keratin Type I Cytoskeletal 10|EHK|BIE|BCIE|KRT10
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 568
- CF® 568
- Clone:
- Clone KRT10/844
- Clone KRT10/844
- Reactivity:
- Human, Mouse
- Human, Mouse
- Host:
- Mouse
- Mouse
- Gene ID:
- 99936
- 99936
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Supplier: VWR Collection
Supplier: KIMBERLY CLARK
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: Merck
Supplier: HEATHROW
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Chemicals
Supplier: VWR Chemicals