Specifications
- Antibody type:Primary
- Antigen name:SH2 Domain Containing leukocyte Protein of 76kDa
- Antigen symbol:SH2 Domain Containing leukocyte Protein of 76kDa
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Form:liquid
- Antigen synonyms:76 kDa tyrosine phosphoprotein|SH2 domain containing leukocyte protein of 76kD|SLP 76|SLP-76 tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|SLP 76 tyrosine phosphoprotein|LCP2|SLP76|Lymphocyte Cytosolic Protein 2|SH2 domain containing lkocyte protein of 76kDa|CG8697|LCP 2|SLP76 tyrosine phosphoprotein.?|LCP2_HUMAN|SH2 Domain Containing Leukocyte Protein 76 KD
- Modification:Tyr145
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
- Concentration:1 ug/ul
- Shipping temperature:4 °C
- Purification:Purified by Protein A.
- Size:100 μg
- Pk:100 µl
Specifications
About this item
The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Type: Primary
Antigen: SLP76
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human