The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
In the mouse, the 1A8 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes. Note: for identification of Ly-C, an alternative antibody, clone RB6-8C5, has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151: 2399 to 2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111 to 123) and has been cited in the literature for identification of Ly-6G/Ly-6C.
Type: Primary
Antigen: LY6G
Clonality: Monoclonal
Clone: 1A8
Conjugation: redFluor® 710
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse
- Catalog No:
- 80-1276-U025
- 80-1276-U100
- Antigen symbol:
- LY6G
- LY6G
- Antigen name:
- Lymphocyte Antigen 6 Complex Locus G
- Lymphocyte Antigen 6 Complex Locus G
- Antigen synonyms:
- Gr1|Gr-1|Ly-6G
- Gr1|Gr-1|Ly-6G
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- redFluor® 710
- redFluor® 710
- Clone:
- 1A8
- 1A8
- Reactivity:
- Mouse
- Mouse
- Host:
- Rat
- Rat
- Gene ID:
- 546644
- 546644
- Isotype:
- IgG2a kappa
- IgG2a kappa
- Flow cytometry:
- Yes
- Yes
- Storage temperature:
- 2...8 °C protected from light
- 2...8 °C protected from light
- Tested applications:
- Flow Cytometry
- Flow Cytometry
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Chemicals
: VWR Collection
: VWR Collection
: KIMBERLY CLARK
: VWR Collection