5269 találat a következőre: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Chaperonin 10 (Cpn10 or Hsp10), is the ~10 kDa mammalian equivalent to GroES of E. coli. Chaperonins play fundamental roles in the folding, assembly, and translocation of other proteins.

Supplier: Enzo Life Sciences

APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770.

Supplier: Enzo Life Sciences

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Supplier: Enzo Life Sciences

Potent stimulator of NKT cells.

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Okadaic acid potassium salt

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Vindoline ≥90% (dry basis)

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Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.

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Na⁺/K⁺ ATPase inhibitor

Supplier: Enzo Life Sciences

Inhibitor of PARG and eNOS

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Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM).

Supplier: Enzo Life Sciences

PI3 kinase inhibitor

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Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.

Supplier: Enzo Life Sciences

Src kinase inhibitor

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Tyrosine kinase inhibitor.

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5alpha-reductase inhibitor

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Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(⁺)-camptothecin. Used in chemotherapy of several different cancers.

Supplier: Enzo Life Sciences

Inhibitor of protein phosphatase.

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ACAT2 inhibitor

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Cyclic tetrapeptide. Inhibitor of chloroplast F1-ATPase (CF1). Does not inhibit the homologous enzymes from chloroplasts of insusceptible plant species or from bacteria or mitochondria.

Supplier: Enzo Life Sciences

Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

Supplier: Enzo Life Sciences

Carciogenesis inhibitor

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Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg.

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Inhibits platelet aggregation. DNA polymerase inhibitor. Shows antifungal activity.

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Precursor of the highly toxic cyclic pentapeptide, nodularin.

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Na⁺/K⁺ ATPase inhibitor

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Anti-inflammatory and immunosuppressive

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TdT inhibitor

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Glucoside of daidzein.

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Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.

Supplier: Enzo Life Sciences

Immunosuppressant.