2429 Résultats pour : "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against human, mouse F4/80, unconjugated.

Supplier: STEMCELL Technologies

Serum-free methylcellulose-based medium with recombinant cytokines (without EPO) for human cells.

Supplier: STEMCELL Technologies

Methylcellulose-based medium with recombinant cytokines (without EPO) for rat cells.

Supplier: STEMCELL Technologies

Interleukin 6 receptor (IL-6R) alpha is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6. IL-6 binds to the membrane-bound non-signaling IL-6R alpha (mIL-6R), and the complex binds to two molecules of gp130 and leads to ‘classical’ IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways (Scheller et al.). In contrast, a soluble form of IL-6R alpha (sIL-6R), which comprises the extracellular portion of the receptor, binds to the secreted IL-6 to form a complex that promotes bioavailability of IL-6. The complex of IL-6 and sIL-6R can bind to gp130 on cells that do not express the IL-6R and are unresponsive to IL-6. This process is known as trans-signaling (Hunter and Jones; Rose-John S). sIL-6R regulates both local and systemic IL-6-mediated events. Elevated levels of sIL-6R have been documented in several disease conditions such as rheumatoid arthritis, myeloma, and Crohn’s disease (Jones et al.; Mihara et al.).

Supplier: STEMCELL Technologies

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that belongs to the four-helix bundle cytokine family and is structurally related to interleukin 6 (IL-6), interleukin 11 (IL-11), leukemia inhibitory factor (LIF), and oncostatin M (OSM). CNTF binds to its receptor CNFTRα and induces formation of a heterodimer of the signal-transducing IL-6 receptor gp130 and LIF receptor (LIFR)-β, which triggers JAK/STAT, ERK, and the PI3K signaling cascades (Schuster et al.). CNTF plays an important role in neurogenesis and the differentiation of neural stem cells and has been suggested to possess a therapeutic role in treating neurological disorders (Ding et al.; Oppenheim et al.). CNTF has also been shown to protect rod photoreceptors from light-induced damage and to have therapeutic effects on retinal degenerative diseases caused by genetic defect or damage induced by toxins, autoantibodies, or strong light (Pernet et al.; Rhee et al.). Another therapeutic role of CNTF has been reported in protecting oligodendrocytes from death induced by apoptosis (Louis et al.). Additionally, CNTF is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into astrocytes (Krencik and Zhang).

Supplier: STEMCELL Technologies

Rabbit polyclonal antibody against human, mouse phosphoSHIP, unconjugated.

Supplier: STEMCELL Technologies

Goat polyclonal antibody against mouse IgM (heavy chain), FITC-conjugated.

Supplier: STEMCELL Technologies

Immunodensity enrichment of untouched human ILC2s.

Supplier: STEMCELL Technologies

Goat polyclonal antibody against rabbit IgG (H+L), AMCA-conjugated.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of CD11b+ cells (e.g. monocytes) from mouse splenocytes or other tissues.

Supplier: STEMCELL Technologies

Dye for staining mouse mammary gland whole mounts.

Supplier: STEMCELL Technologies

Insulin-like growth factor 1 (IGF-I) is a polypeptide which belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway; it also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with interleukin 3 (IL-3), IGF-I stimulates differentiation and proliferation of myeloid cells, and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).

Supplier: STEMCELL Technologies

Defined supplement for single-cell cloning of human ES and iPS cells.

Supplier: STEMCELL Technologies

Methylcellulose-based medium with recombinant cytokines (including EPO) for mouse cells. 1×100 ml bottle.

Supplier: STEMCELL Technologies

Defined supplement for improving survival of human ES and iPS cells in single-cell workflows.

Supplier: STEMCELL Technologies

Serum-free medium for differentiation of human monocytes to macrophages.

Supplier: STEMCELL Technologies

Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.

Supplier: STEMCELL Technologies

Column-free immunomagnetic positive selection of human CD14+ cells for HLA analysis.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of human EpCAM+ cells (e.g. mammary epithelial cells).

Supplier: STEMCELL Technologies

Column-free immunomagnetic positive selection of human CD19+ cells for HLA analysis

Supplier: STEMCELL Technologies

Pour l'estimation de l'efficacité de l'édition du génome par CRISPR-Cas9.

Supplier: STEMCELL Technologies

Positive control for CRISPR-Cas9 genome editing.

Supplier: STEMCELL Technologies

Epidermal growth factor (EGF) is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss). This product is animal component-free.

Supplier: STEMCELL Technologies

Amine-labelling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Supplier: STEMCELL Technologies

Measure and transfer liquids precisely and safely using the Corning® Lambda™ Plus pipettor.

Supplier: STEMCELL Technologies

(C3H x BALB/c) F1 hybrid monoclonal IgG2a antibody against mouse NK1.1 (CD161).

Supplier: STEMCELL Technologies

Kit including BrainPhys™ Neuronal Medium, SM1 Neuronal Supplement, N2 Supplement-A, BDNF and GDNF for culture of ES/iPS cell-derived neurons.

Supplier: STEMCELL Technologies

Serum-free media for maturation of branching lung organoids from human ES and iPS cells.

Supplier: STEMCELL Technologies

Maturation kit for the generation of microglia from human ES and iPS cell-derived microglia precursors.

Supplier: STEMCELL Technologies

Rat monoclonal IgG1, antibody against mouse IFN-gamma, APC-conjugated.