Anti-IFN-gamma Rat Monoclonal Antibody [clone: XMG1.2] (PE)

Rat monoclonal IgG1, antibody against mouse IFN-gamma, PE-conjugated.

Dendritic cells
Macrophages
Nk cells
T cells

The XMG1.2 antibody reacts with mouse interferon-gamma (IFN-γ), a glycosylated type II interferon comprising a homodimer of ~20 kDa subunits in its active form. IFN-γ is produced primarily by activated T lymphocytes and natural killer (NK) cells in response to antigens, including alloantigens, mitogens, and enterotoxins. IFN-γ binds with high affinity to the α subunit of the IFN-γ receptor, resulting in the ligand-induced assembly of a tetrameric α2β2 receptor complex capable of mediating the cellular response to the cytokine through activation of the JAK-STAT pathway. The IFN-γ receptor is expressed on the surface of all nucleated cells. IFN-γ has important functions in a wide range of biological processes, including macrophage activation, mediating the immune response to viruses and bacteria, and modulating cellular proliferation and apoptosis. The XMG1.2 antibody is suitable for detection of intracellular IFN-γ by methods such as flow cytometry, when paired with an appropriate secondary antibody. The XMG1.2 antibody is also widely used in various assays to neutralize the functional activity of IFN-γ.

: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: IFN-gamma
Clonality: Monoclonal
Clone: XMG1.2
Conjugation: PE
Epitope:
Host: Rat
Isotype:
Reactivity: Mouse