Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD40, APC-conjugated.

• B cells

The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation.

Type:
Antigen: CD40
Clonality: Monoclonal
Clone: 5C3
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Chimpanzee, Cynomolgus monkey, Human, Rhesus monkey, Squirrel monkey