12561 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Catechol-O-methyltransferase inhibitor

Supplier: Enzo Life Sciences

CaM kinase inhibitor

Supplier: Enzo Life Sciences

MMP inhibitor

Supplier: Enzo Life Sciences

Antibiotic. Inhibits prokaryote protein synthesis. Binds to the S12 protein of the 30S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria. Mutation in rpsL (the gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Inactivated by aminoglycoside phosphotransferase.

Supplier: Enzo Life Sciences

Produced in Drosophila Schneider 2 (S2) cells. Recombinant human hepsin (aa 45-417) is fused at the C-terminus to a V5-His-tag.

Supplier: Enzo Life Sciences

Potent and selective inhibitor of VEGFR-2 (Flk-1, KDR). It displays a 100-fold greater potency for the unactivated form of the kinase (Ki=0.04µM) compared to the activated form (Ki=4µM).

Supplier: Enzo Life Sciences

BIBB 515 is a potent and selective inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo. BIBB 515 inhibits LDL production in both normolipemic and hyperlipemic hamsters and may represent a novel approach for the development of lipid lowering drugs.

Supplier: Enzo Life Sciences

AMPK activator

Supplier: Enzo Life Sciences

U-0126 (Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile) is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases.

Supplier: Enzo Life Sciences

Active enantiomer of ibuprofen. Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency, ID50=8.9-14 and 7.2-8.2 µM respectively.

Supplier: Enzo Life Sciences

The Screen-Well® epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates at 100 µl or 500 µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.

Supplier: Enzo Life Sciences

SCREEN-WELL® ICCB Known Bioactives Library is a collection of 472 diverse biologically active compounds with defined biological activity and was developed in collaboration with the Harvard Institute of Chemistry and Cell Biology.

Supplier: Enzo Life Sciences

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70^s6k, p33^cdk2 and p34^cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.

Supplier: Enzo Life Sciences

Produced in insect cells. Full length active enzyme.

Supplier: Enzo Life Sciences

Potent naturally occuring diterpenoid κ1-opioid selective agonist. Displays high affinity at κ1-opioid receptors (Ki=4.3 nM).

Supplier: Enzo Life Sciences

Dibenzepine HCl ≥99%

Supplier: Enzo Life Sciences

A potent and selective bradykinin B2 antagonist.

Supplier: Enzo Life Sciences

Serotonin receptor ligand.

Supplier: Enzo Life Sciences

The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

Supplier: Enzo Life Sciences

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. Golgi-associated PIST (PDZ domain protein interacting specifically with TC10) has been characterized by its ability to bind and regulate the expression of membrane associated proteins. A neural isoform of PIST (nPIST) has been linked to autophagy and neurodegenerative disease by mediating the interaction between the delta2-glutamate receptor and Beclin-1, a Bcl-2-interacting protein homolog of the yeast autophagy gene apg6.

Supplier: Enzo Life Sciences

Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.

Supplier: Enzo Life Sciences

The cannabinoid receptors CB1 and CB2 are GPCRs named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). In addition to Delta9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands (e.g. anandamide), and signal via Gi/o alpha subunits to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.

Supplier: Enzo Life Sciences

Actin is one of the major proteins of the cytoskeleton. It regulates contractile potential in muscle tissues and helps to control the shape as well as the motility of non-muscle cells. Actin is expressed in all eukaryotic cells. In higher eukaryotes, there are six isoforms of actin.

Supplier: Enzo Life Sciences

In response to adverse changes in their environment, cells from many organisms increase expression of a class of proteins referred to as heat shock or stress proteins. Hsp25 is the mouse homologue of the human Hsp27 protein, a member of the small heat shock protein family comprised of a diverse group of proteins from ~15 to >30 kDa. Studies on estrogen-induced proteins in breast cancer cells suggest a direct relationship between elevated stress protein expression and neoplasia. Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g., phorbol esters) and calcium ionophores1 and elevated levels of Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock resembles the ecdysteroid and heat shock activation of the drosophila Hsp20 genes. This antibody reacts with both the phosphorylated and the non-phosphorylated forms of Hsp25.

Supplier: Enzo Life Sciences

Transferrin is a serum glycoprotein involved in iron transport. Transferrin exists in two forms, the iron-free Apotransferrin, which binds two Fe3+ ions to generate Ferrotransferrin. Apotransferrin remains tightly bound to its receptor until the complex is recycled to the cell surface, where Apotransferrin is released into the extracellular space to recruit more Fe3+ ions.

Supplier: Enzo Life Sciences

The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

Supplier: Enzo Life Sciences

The cannabinoid receptors CB1 and CB2 are members of the seven-transmembrane family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta 9- tetrahydrocannabinol (delta 9-THC). CB1 and CB2 differ significantly in the length of their extracellular amino terminal domain, which is longer in CB1 (116 residues) than in CB2 (33 residues). The CB1 receptor is expressed primarily in the brain and neuronal tissue, and is highly conserved, exhibiting 97-98% amino acid sequence identity across human, mouse, and rat species. In contrast, expression of the CB2 receptor is absent in normal nervous tissue, with expression most prominent in immune tissue such as the spleen. In addition to delta 9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands, and signal via Gi/o proteins to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.

Supplier: Enzo Life Sciences

Monomeric G-protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways. Oncogenic mutations, which occur in approximately 30% of all cases of human cancer, lead to the stimulation of proliferation and the inhibition of apoptosis.

Supplier: Enzo Life Sciences

The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Supplier: Enzo Life Sciences

PKA (Protein Kinase A), also known as cAMP-dependent protein kinase, phosphorylates serine or threonine residues in target protein in response to elevated levels of cAMP. Inactive PKA exists as a tetrameric protein composed of two regulatory (R) subunits and two catalytic (C) subunits. Activation occurs when two cAMP molecules bind to each R subunit which causes a conformational change that releases the active C subunits.