Potent, selective inhibitor of iNOS (NOS II). The Ki values for inhibition of iNOS (NOS II), nNOS (NOS I), and eNOS (NOS III) by ENIPO are 17, 10.3 and 58.2 µm, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS (NOS II) over nNOS (NOS I) or eNOS (NOS III). This selectivity results from iNOS (NOS II) exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS (NOS I). Ki values for ENIPO binding to iNOS (NOS II) and nNOS (NOS I) are 0.56 and 6 µm, respectively. Accurate determination of the Ki value of ENIPO for eNOS (NOS III) has not been determined but is expected to be 50-fold less than iNOS (NOS II).

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PQ401 ≥98% (by HPLC and UV method)

Supplier: Enzo Life Sciences

Potent inhibitor of insulin-like growth factor I receptor (IGF-IR) signalling and breast cancer cell growth in culture and in vivo.

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Ciprofibrate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

PPARα activator.

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WP-AMC

Supplier: Enzo Life Sciences

DPP substrate

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RGD peptide

Supplier: Enzo Life Sciences

Integrin ligand

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RR-src peptide

Supplier: Enzo Life Sciences

Src kinase substrate

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N,N,2-Trimethyl-5-nitrobenzenesulphonamide (synthetic) ≥98% (by TLC)

Supplier: Enzo Life Sciences

The first selective PDE7 inhibitor (Ki=180 nM).

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Chk2 inhibitor ≥97% (by HPLC)

Supplier: Enzo Life Sciences

Cell-permeable, ATP-competitive, potent inhibitor of Chk2.

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FABP4 inhibitor ≥99% (by HPLC)

Supplier: Enzo Life Sciences

A cell-permeable, potent, and selective inhibitor of FABP4.

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PDGF receptor tyrosine kinase inhibitor IV ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Cell-permeable PDGFR inhibitor with antiproliferative properties.

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Tyrphostin A9 ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

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Tranylcypromine hemisulphate ≥99%

Supplier: Enzo Life Sciences

Demethylase inhibitor

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Aristolochic acid sodium salt ≥97%

Supplier: Enzo Life Sciences

Water soluble form of aristolochic acid.

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L-744,832 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.