12561 Results for: "ENZO LIFE SCIENCES"

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p53 activator.

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PARP inhibitor

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Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3 µm IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µm H₂O₂). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50 µm.

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Hsp60 is a member of the chaperonin family of heat shock proteins, with homologs functioning in the cytosol and mitochondria to fold nascent and aggregated proteins. Hsp60 is the eukaryotic homolog of the E. coli GroEL protein, and forms a multimeric complex in the mitochondria with Hsp10 (Cpn10) to form a large central cavity in which ATP-dependent protein folding takes place. TRiC/CCT, a eukaryotic relative of Hsp60, is expressed in the cytosol and participates in the folding of actin and tubulin substrates, but lacks any association with an Hsp10-like co-factor.

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Highly selective NK-3 neurokinin receptor agonist

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Orange 552 dUTP (5-TAMRA-dUTP) can replace TTP in reactions in which it serves as a substrate for E. coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase. Fluorescently labeled probes can be prepared with this fluorescent nucleotide by a variety of methods including nick translation, cDNA labeling and 3’-end labeling. Probes generated by these methods are suitable for use for the identification of specific sequences by in situ hybridization procedures on fixed cells and tissues by direct fluorescence detection. Orange 552 dUTP can also be used for multicolor fluorescence labeling.

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Produced in E. coli. Human 14-3-3epsilon is fused at the N-terminus to a GST-tag.

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Recommended Applications: ELISA, IF, IHC (PS), WB

Species reactivity: Human, Mouse

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Produced in CHO cells. Human full-length PTX3.

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Acetyl-CoA inhibitor

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Selective COX-1 inhibitor (IC50=9nM). Shows 700-fold more selectivity over COX-2 (IC50=6.3µM). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2, and dermal PGE2 production. Orally active in rat.

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Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

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Immunoglobulin G (IgG) is an immunoglobulin monomer consisting of two (gamma) heavy chains and two light chains. Each IgG molecule contains two antigen binding domains and a single effector (Fc) domain. Assay Designs offers isotyping kits and antibodies in a variety of formats for the detection of human, mouse, rabbit, rat, sheep, and goat IgG.

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Ca²⁺ channel blocker.

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Host: Mouse, Isotype: IgG2b

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Produced in E. coli.

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Hepatotox Set™ 1

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PP2A inhibitor

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Recommended Applications: ELISA, IHC, IP, WB

Species reactivity: Human, Hamster, Cat

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TLR9 ligand.

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The PATHO-GENE® HPV type 6/11 probe is a mixture of biotin-labeled HPV 6 and HPV 11-specific probes in buffered formamide and hybridisation enhancers.

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Ultra-sensitive human growth hormone ELISA kit enabling detection of HGH in serum, plasma, saliva and tissue culture media in just 2,5 hours.

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Recommended Applications: IF, IP, WB

Species reactivity:

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Recommended Applications: Flow Cytometry

Species reactivity: Human

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Anti-VDAC Rabbit Polyclonal Antibody

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HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.

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PDE inhibitor

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Caspase substrate

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Biosynthesis in endothelial cells. Induces vasodilation, inhibits platelet aggregation by receptor-mediated stimulation of adenylate cyclase. Cytoprotective. Fibrinolytic. Half-life under physiological conditions is 2 minutes.

Supplier: ENZO LIFE SCIENCES

For the quantitative determination of nitrite and nitrate levels in culture supernatants, plasma, serum, saliva, and urine from any species.