12561 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

PGD2 is a principal metabolite of arachidonic acid, catalyzed by PGD synthases primarily in hematopoietic and neural cells. Although PGD2 is traditionally considered a pro-inflammatory mediator, the actions of PGD2 and its metabolites have been shown to exert concentration-dependent pro- and anti-inflammatory effects on leukocyte development, function, and apoptosis.

Supplier: Enzo Life Sciences

Interleukin-8 (IL-8) is a cytokine produced by monocytes, macrophages, neutrophils, lymphocytes, dermal fibroblasts, keratinocytes, vascular endothelial cells, melanocytes, hepatocytes and various tumor cell lines. It is also a member of the CXC family of chemokines, displaying chemotactic activity for neutrophils and T cells.

Supplier: Enzo Life Sciences

Prostaglandin F2alpha (PGF2alpha) is formed in a variety of cells from PGH2, which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthetase. PGF2alpha is often viewed as an antagonist to PGE2 due to their opposing effects on various tissues. PGF2alpha is a potent bronchoconstrictor and has been implicated in asthma attacks. PGF2alpha is also involved in reproductive functions including corpus luteum regulation, uterine contractions, and sperm motility. This has led to its use in terminating pregnancies and inducing labor at term. High levels of PGF2alpha have also been associated with preeclampsia.

Supplier: Enzo Life Sciences

Small molecule inducer of autophagy important for neurodegenerative disease research.

Supplier: Enzo Life Sciences

Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).

Supplier: Enzo Life Sciences

Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC50=44 and 88nM respectively). VEGFR2 IC50=0.32μM; c-fms IC50=30μM.

Supplier: Enzo Life Sciences

PARP-3 is part of the PARP family of enzymes that modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.

Supplier: Enzo Life Sciences

Active recombinant human SGK-1 (truncated NT 60 aa) produced in Sf9 cells using an N-terminal GST-tag.

Supplier: Enzo Life Sciences

Cysteine string protein (CSP) is a 34 kDa rat brain protein localized to the cytoplasmic surface of the synaptic vesicle. CSP is believed to perform similar functions in the assembly of synaptic vesicle proteins which are essential to membrane trafficking.

Supplier: Enzo Life Sciences

SHPS-1 is a member of the gene family called the signal regulatory proteins of which there are at least fifteen members. SHPS-1 is a substrate of many activated tyrosine kinases such as Insulin receptor and EGFR, amongst others. SHPS-1 has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

Supplier: Enzo Life Sciences

Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.

Supplier: Enzo Life Sciences

Produced in E. coli. Untagged USP2 catalytic domain.

Supplier: Enzo Life Sciences

The Rab family of GTP-binding proteins are members of the Ras superfamily of small G proteins, and participate in multiple steps of the membrane trafficking. Rab3A participates in the fusion of synaptic vesicles during neurotransmitter release, a process regulated by GDP/GDP exchange cofactors such as GAP, GDI, GRF, and rabphilin. Rab4 regulates recycling of proteins from the early endosome to the surface of many cell types, regulating glucose transporter and transferrin receptor cell surface localization. Rab5 regulates the fusion of plasma membrane-derived clathrin-coated vesicles with early endosomes and homotypic fusion among early endosomes.

Supplier: Enzo Life Sciences

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via an N-acetylglucosamine unit on the oligosaccharide, and hydrophobic amino acids that are exposed in the denatured conformation.

Supplier: Enzo Life Sciences

Produced in E. coli. Recombinant protein (130 aa).

Supplier: Enzo Life Sciences

Produced in E. coli. Contains 110/220 amino acids.

Supplier: Enzo Life Sciences

Produced in E. coli. Contains 126, 110/236 amino acids.

Supplier: Enzo Life Sciences

Recombinant Zika Virus (Uganda strain) NS1 protein, incorporating a C-terminal 6x His tag produced in mammalian HEK293 cells.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Mephytoin 4-hydroxylase family of CYPs. Metabolizes anti-depressants. Cytochrome P-450 2C19 (CYP2C19) is a sex-dependent steroid hydroxylase.

Supplier: Enzo Life Sciences

Recommended Applications: IF, WB

Species reactivity: Human, Rodent, Monkey

Supplier: Enzo Life Sciences

Recommended Applications: IHC, WB

Species reactivity: Mouse, Primate

Supplier: Enzo Life Sciences

Recommended Applications: IF, IHC (PS), WB

Species reactivity: Human

Supplier: Enzo Life Sciences

Immunoglobulin G (IgG) is an immunoglobulin monomer consisting of two (gamma) heavy chains and two light chains. Each IgG molecule contains two antigen binding domains and a single effector (Fc) domain. Assay Designs offers isotyping kits and antibodies in a variety of formats for the detection of human, mouse, rabbit, rat, sheep, and goat IgG.

Supplier: Enzo Life Sciences

Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Prod. No. BML-GR239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not.

Supplier: Enzo Life Sciences

Recommended Applications: Flow Cytometry, IF

Species reactivity: Human

Supplier: Enzo Life Sciences

Recommended Applications: ICC, IHC, WB

Species reactivity: Human

Supplier: Enzo Life Sciences

Rat lipocalin-2 is also called rat NGAL, as it is the ortholog of human neutrophil gelatinase-associated lipocalin (NGAL). Rat NGAL is a 25-kDa alpha 2-microglobulin-related protein or neu-related lipocalin. It is expressed by neutrophils and various epithelial cells, including cells of the renal proximal tubules. It is involved in physiological processes such as the binding of siderophore iron and tissue growth and regeneration. It is upregulated in a variety of pathological situations including infection, inflammation, ischemia-reperfusion and in certain adenocarcinomas.

Supplier: Enzo Life Sciences

Anti-GHRL Mouse Monoclonal Antibody [clone: 45]

Supplier: Enzo Life Sciences

Sensitive ELISA kit enabling detection of 12(S)-HETE in culture supernatants and plasma from any species.