- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Rat
- Environmentally Preferable:
- Tag sequence:DDDDK Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C.
- Protein synonyms:PC Cell-derived Growth Factor|Proepithelin|PEPI
- Protein/peptide name:Progranulin
- Purity:>95% (SDS-PAGE)
- Sequence:1-593
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Fusion-Tag: DDDDK Tag
This recombinant proteins is for research use only.