- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Tag sequence:C-6 His tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Protein synonyms:Natural Killer-Associated Transcript 2|NKAT2|KIRCL23|NKAT-2|NKAT2a|KIR2DL3|p58 NK Receptor CL-6|NKAT2b|MHC Class I NK Cell Receptor|CD158b2|KIR-023GB|p58.2 MHC Class-I-Specific NK Receptor|Killer Inhibitory Receptor cl 2-3|CD158 Antigen-like Family Member B2|p58 Natural Killer Cell Receptor Clone CL-6|Killer Cell Immunoglobulin-like Receptor 2DL3
- Protein/peptide name:KIR2DL3
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:25.4 kD
- Sequence:His22-His245
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumour cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognises class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.