- Antibody type:Primary
- Antigen name:beta synuclein
- Antigen symbol:SNCB
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Sheep
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Rat
- Environmentally Preferable:
- Epitope:aa: 108-125
- Cross adsorption:No
- Format:Lyophilized
- Immunogen:A synthetic peptide (IEPLMEPEGSYEDPPQE) of human beta synuclein protein (aa: 108-125) conjugated to diptheria toxid has been used as the immunogen.
- Size:100 µg
- Pk:100 µG
Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
Known to be specific for beta synuclein.
Application Information:
IHC. A working concentration of 1 µg/ml is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: beta synuclein
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: aa: 108-125
Host: Sheep
Isotype: IgG
Reactivity: Rat