Primary human dermal lymphatic endothelial cells (HDLEC) are a subpopulation of the human dermal endothelial cells. They are isolated from the dermis of juvenile foreskin and adult skin (different locations) from a single donor.

Lymphatic vessels transport excess fluids from tissues to the circulatory system and are a major component of the immune system. The transported fluid is nearly cell free. The vessels are highly permeable, because they lack a continuous basal membrane. Lymphatic endothelial cells are involved in pathological alterations of the lymphatic system. During tumor lymphangiogenesis, the lymphatic endothelial cells build new vessels that infiltrate tumors, attract tumour cells, and induce tumor cell metastasis.