Anti-ID4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog # BOSSBS-6669R-A680

Supplier: Bioss

Catalog # BOSSBS-6669R-A680

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
ID4
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human
Environmentally Preferable:
Epitope:
61-160/161
Form:
Liquid
Gene ID:
3400
Antigen synonyms:
bHLHb27|Class B basic helix-loop-helix protein 27|Id4|Inhibitor of DNA binding 4 dominant negative helix loop helix protein|DNA binding protein inhibitor ID 4|DNA-binding protein inhibitor ID-4|Inhibitor of DNA binding 4|DNA binding protein inhibitor ID4|ID 4|ID4_HUMAN|IDB4
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
18 kDa
Storage temperature:
Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ID4
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerise with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Type: Primary
Antigen: ID4
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 61-160/161
Host: Rabbit
Isotype: IgG
Reactivity: Human