Anti-Chloride Channel 5 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-10307R-A680

Anti-Chloride Channel 5 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-10307R-A680

Antibody type:
Primary
Antigen name:
Chloride Channel 5
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Environmentally Preferable:
Epitope:
1-100/746
Form:
Liquid
Antigen synonyms:
H+/Cl- exchange transporter 5|NPHL2|CLC5|Chloride channel protein 5|CLCN5_HUMAN|DENTS|hCIC-K2|NPHL1|XLRH|Chloride transporter ClC-5|XRN|CLCK2|ClC-5|CLCN5
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
83 kDa
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human Chloride Channel 5/CLC5
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterised by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterised by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.

Type: Primary
Antigen: Chloride Channel 5
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 1-100/746
Host: Rabbit
Isotype: IgG
Reactivity: