AUDA ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Novel inhibitor of soluble epoxide hydrolase (IC50=18nM and 69nM for the mouse and human enzymes respectively). Produces a hypotensive effect in angiotensin-infused rats and prevents and reverses cardiac hypertrophy in mouse models of cardiac hypertrophy.
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Midostaurin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
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Alamethicin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.
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DMNQ ≥99% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inducer of intracellular ROS generation.
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α-Hydroxyalprazolam ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Metabolite of alprazolam.
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H-7 dihydrochloride ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.
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Dexamethasone ≥99% (by TLC)
Supplier: ENZO LIFE SCIENCES
Glucocorticoid receptor ligand
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SB216763 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.
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Palmityltrifluoromethylketone ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).
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Latrunculin A ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Ultra-pure; inhibits actin polymerization
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Ilimaquinone ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
ADP-ribosylation factor inhibitor
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L-744,832 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
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: GRANT INSTRUMENTS
: BOCHEM
: VWR Collection
: DWK Life Sciences
: Thermo Fisher Scientific
: VWR Collection
: Oxford Nanopore Technologies
: Industrial Physics
: AAT BIOQUEST
: Integra
: Palbam
: VWR Collection
: Integra
: VWR Collection
: FACELLITATE
: NANOENTEK
: Greiner Bio-One