42864 Results for: "ProSci Inc."

Supplier: ProSci Inc.

Sirtuin-1 is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Sirtuin-1 emerged as critical regulator of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Sirtuin-1 has been suggested as potential biomarker for tumorigenesis.

Supplier: ProSci Inc.

Anti-GOLM1 Goat Polyclonal Antibody

Supplier: ProSci Inc.

NECAP2 belongs to the NECAP family. The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Adaptin ear-binding coat-associated protein 2 can interacts with AP1G1 and AP2A1 components of the adapter protein complex AP-1 and AP-2. It also interacts with the GAE domain proteins GGA1, GGA2 and GGA3.

Supplier: ProSci Inc.

Anti-RAD17 Rabbit Polyclonal Antibody

Supplier: ProSci Inc.

Anti-CD69 Hamster Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: ProSci Inc.

Anti-STK35 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-SUV39H2 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-STX1A / STX1B Goat Polyclonal Antibody

Supplier: ProSci Inc.

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity.

Supplier: ProSci Inc.

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Supplier: ProSci Inc.

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Supplier: ProSci Inc.

FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
CATALYTIC ACTIVITY: Cleavage of peptide bonds with very broad specificity.
SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure. This subunit can be displaced by the equivalent immune-specific subunit PSMB10.

Supplier: ProSci Inc.

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

Supplier: ProSci Inc.

SIMILARITY: Contains 4 EF-hand domains.
SUBCELLULAR LOCATION: L-CaBP1 is associated most likely with the cytoskeletal structures whereas S-CaBP1 is localized at or near the plasma membrane.
TISSUE SPECIFICITY: Retina and brain. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.

Supplier: ProSci Inc.

Human Interleukin-36 alpha (IL-36 alpha) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36 alpha is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36 alpha is the only IL-1 family member found to be expressed on T-cells. IL-36 alpha and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36 alpha inhibits PPAR gamma expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36 alpha, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36 alpha may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

Supplier: ProSci Inc.

The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha.The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987).

Supplier: ProSci Inc.

TM9SF1 may function as channel, small molecule transporter or receptor.

Supplier: ProSci Inc.

EVX1 is a member of the vertebrate eve-related homeo box family. This protein acts as a transcriptional repressor. A similar protein in mice is critical for early embryogenesis. This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis.

Supplier: ProSci Inc.

The function remains unknown.

Supplier: ProSci Inc.

Anti-SOX21 Goat Polyclonal Antibody

Supplier: ProSci Inc.

The function remains unknown.

Supplier: ProSci Inc.

CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukomia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.

Supplier: ProSci Inc.

Anti-TFEC Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-SNTG1 Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-THRA Goat Polyclonal Antibody

Supplier: ProSci Inc.

Anti-LEF1 Goat Polyclonal Antibody

Supplier: ProSci Inc.

SLC25A24 is a calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. It may act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Supplier: ProSci Inc.

SLC35F2 is a putative solute transporter.

Supplier: ProSci Inc.

THOC1 is part of the TREX (transcription/export) complex, which includes TEX1, THO2, ALY, and UAP56.HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).

Supplier: ProSci Inc.

Anti-LAT Goat Polyclonal Antibody