"Other Essentials"

Supplier: Bioss

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Supplier: Bioss

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Supplier: Ansell

These sleeves contain a very high proportion of Dyneema® fibres which are as strong as steel fibres but much lighter and more flexible.

Supplier: KIMBERLY CLARK

KIMTECH PREP® SCOTTPURE™ Wipers are designed for wiping tasks where precision and reliability are essential.

Supplier: MERCK PRODUCTION CHEMICALS

Parteck® SI 200 (Sorbitol), EMPROVE® EXPERT Ph. Eur., BP, JP, NF, E420 suitable for use as excipient

Supplier: MERCK PRODUCTION CHEMICALS

Parteck® SI 400 (Sorbitol), EMPROVE® EXPERT E420, Ph. Eur., NF, BP, JSFA suitable for use as excipient, SAFC®

Supplier: MERCK PRODUCTION CHEMICALS

Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present.
Corresponds to Ph. Eur., BP, USP, FCC

Supplier: Antibodies.com

Human MTHFR ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human MTHFR in serum, plasma, tissue homogenates or other biological fluids.

Supplier: Bioss

Essential for the assembly of the distal half of centrioles, required for centriole elongation.

Supplier: Antibodies.com

Human MTHFR ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human MTHFR in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ProSci Inc.

Zfpm1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. It is essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family. Zfpm1 may be involved in regulation of some genes in gonads and involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

Supplier: Bioss

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Supplier: Bioss

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Supplier: Merck

The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques. The CRM may also find the following uses:

Supplier: ProSci Inc.

IKK alpha Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF alpha and bacteria product LPS. NF-kappa B is associated with I kappa B proteins in the cell cytoplasm, which inhibit NF-kappa B activity. The long-sought I kappa B kinase (IKK), which phosphorylates I kappa B, and mediates I kappa B degradation and NF-kappa B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta ). IKK alpha and IKK beta interact with each other and both are essential for the NF-kappa B activation. IKK alpha specifically phosphorylates I kappa B-alpha. IKK alpha is expressed in a variety of human tissues.

Supplier: ProSci Inc.

IKK beta Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF alpha , and bacteria product LPS. NF-kappa B is associated with I kappa B proteins in the cell cytoplasm, which inhibit NF-kappa B activity. The long-sought I kappa B kinase (IKK), which phosphorylates I kappa B, and mediates I kappa B degradation and NF-kappa B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta ). IKK alpha and IKK beta interact with each other and both are essential for NF-kappa B activation. IKK beta phosphorylates both I kappa B-alpha and I kappa B-beta. IKK beta is expressed in variety of human tissues.