"Other Essentials"

Supplier: Abcam

Anti-PRDM1/Blimp1 antibody [EPR25163-80] is a Rabbit Monoclonal antibody that is used in PRDM1/Blimp1 IHC-P, IP, Western Blot. Suitable for Human samples. PRDM1(Blimp1) is a transcription factor that plays a crucial role in the differentiation of plasma cells and CD8+ effector T cells. It regulates the expression of genes involved in immune responses and is essential for the terminal differentiation and function of various immune cell.

Supplier: Abcam

Recombinant Human IKK gamma/NEMO protein is a Human Full Length protein, in the 1 to 419 aa range, expressed in Baculovirus infected Sf9, with =95% purity and suitable for SDS-PAGE, WB.

Supplier: Abcam

Anti-KMT2B/MLL4 C-terminal antibody [EPR27970-7] is a Rabbit Monoclonal antibody that is used in KMT2B/MLL4 ChIP-seq, Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. KMT2B (MLL4) is a histone methyltransferase that specifically methylates histone H3 at lysine 4 (H3K4), playing a key role in gene regulation. It is involved in chromatin remodeling and is essential for the regulation of developmental genes and stem cell differentiation. Mutations in KMT2B have been linked to various cancers and developmental disorders.

Supplier: Abcam

Anti-DDX6 antibody [EPR27016-10] is a Rabbit Monoclonal antibody that is used in DDX6 ICC/IF, IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. DDX6 is an RNA helicase involved in the regulation of mRNA metabolism, including translation suppression and mRNA degradation. It plays a crucial role in the formation of P-bodies and stress granules, which are essential for the storage and decay of mRNAs. Additionally, DDX6 is required for microRNA-induced gene silencing, impacting gene expression regulation.

Supplier: Abcam

Anti-Brd4 antibody [EPR29186-23] is a Rabbit Monoclonal antibody that is used in Brd4 Dot Blot, IHC-P, Western Blot. Suitable for Human, Mouse, Rat samples. BRD4 (Bromodomain-containing protein 4) is a chromatin reader protein that recognises and binds acetylated histones, playing a crucial role in transcription regulation. It is part of the BET (bromodomain and extra terminal domain) family, which includes BRD2, BRD3, and BRDT. BRD4 is involved in maintaining epigenetic memory across cell divisions and is essential for the expression of certain oncogenes in various cancers.

Supplier: ROBU GLASFILTER

ROBU® Filter Crucibles with intergrated VitraPOR® filter provide efficient filtration for laboratory applications. Made from durable materials, these crucibles are designed for high-performance filtration, offering reliable separation of solids and liquids. Ideal for gravimetric analysis and other precise filtration processes.

Supplier: Abcam

Anti-HIRA/HIR antibody [EPR25299-11] is a Rabbit Monoclonal antibody that is used in HIRA/HIR IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. HIRA (Histone Cell Cycle Regulator) is a histone chaperone that facilitates replication-independent chromatin assembly by placing the variant histone H3.3 into nucleosomes. It plays a crucial role in the formation of senescence-associated heterochromatin foci (SAHF), which are involved in the irreversible cell cycle changes in senescent cells. Additionally, HIRA is essential for the periodic repression of histone gene transcription during the cell cycle.

Supplier: FUJIFILM WAKO CHEMICALS

Monothioglycerol (MTG) can be used as an alternative for 2-mercaptoethanol (2ME) since it exhibits comparable performance to 2ME when it is added to a medium in the culture of mouse ES D3 strain cells.

Supplier: Cytiva

Capto™ HiRes Q and Capto™ HiRes S are prepacked columns for high-resolution purification of proteins and other biomolecules by ion exchange chromatography. They are well-suited for the preparation of highly pure proteins for structural studies and for protein analysis.

Supplier: Abcam

Anti-FAK (phospho Y397 + Y576 + Y925) antibody [RM1141] is a Rabbit Recombinant Multiclonal antibody that is used in FAK (phospho Y397 + Y576 + Y925) Dot Blot, Western Blot. Suitable for Human, Mouse, Rat samples. FAK (PTK2) is a non-receptor protein-tyrosine kinase which is involved in regulation of a number of essential cellular processes, including cell cycle progression, cell migration, actic cytoskeleton organisation and formation of focal adhesions. FAK is activated by phosphorylation and recruited to focal adhesions in response to integrin signalling. Aberrant expression of FAK may play a role in tumor formation, including ovarian, breast and non-small cell lung cancers.

Supplier: Abcam

Anti-CRBN antibody [EPR28739-64] is a Rabbit Monoclonal antibody that is used in CRBN Flow Cytometry (Intra), IP, Western Blot. Suitable for Human, Mouse samples. Cereblon (CRBN) is a multifunctional protein located in the cytoplasm, nucleus, and peripheral membranes of the human tissues. CRBN is closely related to the proliferation and metabolism of normal cells as well as tumor cells.It is part of the CRL4 CRBN ubiquitin E3 ligase complex, which is crucial for the action of immunomodulatory drugs (IMiDs) like lenalidomide and pomalidomide. These drugs bind to CRBN, leading to the degradation of transcription factors Ikaros and Aiolos, which are essential for myeloma cell survival. Additionally, novel cereblon E3 ligase modulators (CELMoDs) are being developed to overcome resistance to IMiDs, offering new therapeutic options for patients with CRBN mutation.

Supplier: Abcam

Anti-Fas antibody [EPR24898-74] is a Rabbit Monoclonal antibody that is used in Fas IHC-Fr, IHC-P, IP, Western Blot. Suitable for Mouse samples. FAS, also known as CD95 or APO-1, is a cell surface receptor that plays a significant role in regulating apoptosis (programmed cell death). FAS is crucial for inducing apoptosis in cancer cells. When FAS binds to its ligand (FASL), it triggers a cascade leading to cell death, which is essential for eliminating cancer cells.FAS was identified as an independent prognostic marker for recurrence free survival in breast cancer, with large variation in expression by receptor subtypes. Interestingly, the prognostic effect of CD8+ TILs in ER-negative disease was only valid for tumors with a high FAS expression.FAS expression might therefore act as a predictive factor for new emerging therapies.Researchers are exploring ways to enhance FAS signaling to prevent cancer relapse and improve the durability of immunotherapy responses.

Supplier: VWR Collection

PFAS PP short thread caps or PE snap ring caps, light green, with hole. White silicone/transparent polypropylene, for PFAS analysis.

Supplier: Abcam

Mouse Monoclonal CD18 antibody. Low endotoxin, Azide free. Suitable for IP, Flow Cyt, WB, FuncS and reacts with Human samples. Immunogen corresponding to Cell preparation containing ITGB2 protein.

Supplier: TEMPSHIELD

Hand protection for industrial settings working with LNG or liquid nitrogen.

Supplier: TEMPSHIELD

Waterproof Cryo-Grip® gloves offer improved grip on small objects while protecting hands and arms when working in hasardous, ultra-cold environments.