"Other Essentials"

Supplier: Abcam

Essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. Used as an antidepressant, anxiolytic and sleep aid. Precursor to niacin, indole alkaloids, serotonin and melatonin.

Supplier: Abcam

Spermine is a biogenic polyamine formed from spermidine and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. Spermine tetrahydrochloride is used for precipitation of DNA from low salt aqueous buffers.

Supplier: Abcam

Highly sensitive, photo-stable fluorescent probe for quantification of low concentrations of nitric oxide (NO). More sensitive to nitric oxide (NO) than DAF-2, More photo-stable and less pH sensitive than DAF-2, Not as cell-permeable as the diacetate derivative, DAF-FM DA , but it does not need to be activated by cytosolic enzymes. Essentially nonfluorescent until it reacts with NO to form a fluorescent benzotriazole.

Supplier: Abcam

Widely used blue fluorescent thiol-reactive dye. Essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.

Supplier: Abcam

Monochlorobimane is a cell-permeant probe for quantifying glutathione levels in cells. It is essentially nonfluorescent until it reacts with a thiol group. It readily reacts with several low molecular weight thiols, including cysteine, glutathione, N-acetylcysteine, mercaptopurine, peptides and plasma thiols. The glutathione conjugate of monochlorobimane has an excitation/emission maxima ~394/490 nM.

Supplier: Abcam

Essential polyunsaturated fatty acid. PPAR activator. Induces apoptosis. Augments cellular oxidant status and induces mitochondrial dysfunction. Modulates the infla mMatory process and regulates neutrophil function. Stimulates thromboxanes and prostaglandin production. Shows antithrombotic effects in vivo. Orally active.

Supplier: Abcam

Fluorescent probe for measuring protein conformational changes and quantitative measurement of protein hydrophobicity processes that modify the exposure of the probe to water. Essentially nonfluorescent in water. Fluorescent when bound to membranes (q.y. ~0,27) or hydrophobic domains of proteins (q.y. ~0,72). Fluorescence enhanced by cyclodextrins. Can be used to provide a sensitive method for separating and analyzing cyclodextrins by capillary electrophoresis.

Supplier: Abcam

Essential amino acid for human development. Important in many functions, including acting as a hepatoprotectant, an acetominophen poisoning antidote, and a urinary acidifier. Serves as a chelating agent for heavy metals. Common methyl-group donor in vivo.

Supplier: G-Biosciences

Detergents are essential for protein solubility during protein extraction and sample preparation, especially when working with hydrophobic proteins. The presence of high concentrations of detergents in protein samples can impair ELISA, IEF, protease digestion of proteins and suppress peptide ionisation when analysed by mass spectrometry.

Supplier: Abcam

Anti-p63 antibody [4A4] is a mouse monoclonal antibody designed to detect p63, a transcription factor essential for the development and maintenance of epithelial tissues. Validated for immunohistochemistry (IHC) and reacts with human samples. - Cited in over 150 publications - Trusted by researchers since 2002.

Supplier: Abcam

Abundant essential n-3 polyunsaturated fatty acid in the CNS, shown to play a major anti-inflammatory role. Prevents LPS-induced dendritic cell maturation, characterised by a lack of proinflammatory cytokine production. Improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Inhibits Aβ1-42 fibrillation and toxicity in vitro. Retinoid X receptor (RXR) ligand.

Supplier: Abcam

Anti-CLEC9A antibody [EPR24271-117] is a Rabbit Monoclonal antibody that is used in CLEC9A Flow Cytometry (Intra), IHC-P. Suitable for Mouse samples. C-type lectin domain containing 9A (Clec9a) is an endocytic receptor that recognizes danger signals exposed on necrotic cells. It's essential for the cross-presentation of dead cell-associated antigens, which is crucial for initiating innate immune responses.

Supplier: Abnova

This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the IKBKG protein, and the other against the specific S31 phosphorylated site of IKBKG for use in Proximity Ligation Assay

Supplier: Abcam

Anti-Desmin rabbit polyclonal Cytoskeleton Marker antibody that is designed to detect desmin, a muscle-specific type III intermediate filament essential for proper muscular structure and function. Used in Desmin IHC, ICC/IF. Suitable for Human, Mouse, Rat samples. - Trusted by researchers since 2004 - Top cited Desmin antibody with over 200 publications.

Supplier: Abcam

Anti-KDM4B/JMJD2B antibody [EPR25240-51] is a Rabbit Monoclonal antibody that is used in KDM4B/JMJD2B IHC-P, Western Blot. Suitable for Human samples. KDM4B, also known as JMJD2B, is an enzyme that demethylates histone H3 at lysine 9 (H3K9), playing a pivotal role in altering the histone code. This enzyme is essential for chromatin remodeling and regulating gene expression, impacting critical processes like brain development and cancer progression.

Supplier: Abcam

Anti-Anti antibody [RP23040238] is a Rabbit Recombinant Multiclonal antibody that is used in Anti ICC/IF, Western Blot. Suitable for Human, Mouse samples. Liver arginase, particularly arginase-1 (ARG1), plays a significant role in cancer by regulating the proliferation, migration, and apoptosis of cancer cells. It contributes to immunosuppression and promotes the synthesis of polyamines, which are essential for tumor growth. Targeting arginase activity is being explored as a potential therapeutic strategy to inhibit cancer progression.