Supplier: Alpha Laboratories

PASTEUR PIPETTE 1ML, SMALL BULB, STER/20 1 * 500 items

Supplier: Alpha Laboratories

PIPETTE PASTEUR ULTRA MICRO 25 DROPS/ML 1 * 500 items

Supplier: Alpha Laboratories

DEEP WELL PLATE, 1.2ML, PS, NON STERILE 1 * 24 items

Supplier: Alpha Laboratories

[EN]GRADUATED PIPETTE 3.2ML, GRADUATED @

Supplier: Alpha Packaging

Radiation/radioactive waste bag clear boxed, 455x760mm pk/50 1 * 50 items

Supplier: Alpha Laboratories

SAMPLETITE PRIME JAR 120ML CLEAR NS 1 * 500 items

Supplier: Roth Carl

A-CHACONINE 1 * 5 mg

Supplier: Alpha Laboratories

SCREW CAP APEX BLUE NS PK OF 500 1 * 500 items

Supplier: Alpha Laboratories

RACK 4-WAY INTERLOCKING COMBIRACK ASSORTED COLOURS AUTOCLAVABLE PACK OF 5 WITH 4 ORIENTATIONS TO ACCOMMODATE 0.5ml 1.5ml 2.0ml 15ml and 50ml 1 * 5 items

Supplier: Alpha Laboratories

SCREW CAP APEX GREEN NS PK OF 500 1 * 500 items

Supplier: Merck Millipore (Calbiochem‎)

Tumor Necrosis Factor-A Antagonist 1 * 1 mg

Supplier: Alpha Laboratories

SCREW CAP APEX VIOLET NS PACK OF 500 1 * 500 items

Supplier: Alpha Laboratories

Sample transport system for mailing of category B biological samples to UN3373 P650 packaging instruction Rigid Flexible 95 330G 194 x 125 x 68mm 1 * 25 items

Supplier: Roth Carl

a-Solanine 1 * 10 mg

Supplier: Alpha Packaging

ZIP BAG write on sample bag, re-sealable, 110x137mm, pk1000 1 * 1.000 items

Supplier: Alpha Laboratories

Tip 1-200µl Universal Bevelled Tip Graduated Non-Sterile 50mm in length Fastrak® Tip Refill System 10 racks of 96 in a refill tower 1 * 960 items

Supplier: Alpha Laboratories

Serological Pipette Graduated 5ml Plastic Plugged Sterile Sterilin Individually Paper Peel Wrapped 4 Packs of 50 ideal for tissue c ulture work 1 * 200 items

Supplier: Alpha Laboratories

0.5ML THIN WALL FLAT CAP PCR TUBE NATURAL 1 * 1.000 items

Supplier: Alpha Laboratories

BEUTEL 95KPA C3 GRÖßE 305 X 403 MM FÜR DEN TRANSPORT VON BIOLOGISCHEN PROBE

Supplier: Alpha Laboratories

RACK 100-POSITION FREEZER RACK HINGED LID 10 X 10 ARRAY ASSORTED TEMPERATURE 90C TO 120C PACK OF 5 FITS 1.5ML 2.0ML MICROTUBES OR 1.2ML CRYOVIALS 1 * 1 items

Supplier: Alpha Laboratories

Tip Eppendorf-fit Graduated 1000-10000µl Racked Sterile 161mm in length 2 racks of 25 for accurate measurement of large volume solut ions 1 * 50 items

Supplier: Alpha Laboratories

Tip 100-1000µl FlexTop Wide Orifice Extended-Length Aerogard® Filtered Racked Sterile 89mm in length ZAP™ Premier 1 * 576 items

Supplier: Alpha Laboratories

CALIBRATED MICROPIPETTES GLASS CAPILLARIES WITH EDTA 100 UL INCLUDES 15 INCH ASPIRATOR TUBE ASSEMBLY VIAL OF 250 FOR MICRO-VOLUME TRANSFER 1 * 250 items

Supplier: Alpha Laboratories

Empty Racks for 10, 20, 200 and 250µl Tips Every rack includes a patented lock-down system 1 * 10 items

Supplier: LGC Standards PROMOCHEM

1-(4-CHLOROBENZYL)-3-[(2RS)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]IMIDAZOLIUM CHLORIDE 1 * 100 mg

Supplier: Thermo Scientific

N1-[4-(trifluoromethoxy)phenyl]-2-chloroacetamide, 97% 1 * 10 g

Supplier: Thermo Scientific

N1-[4-(trifluoromethoxy)phenyl]-2-chloroacetamide, 97% 1 * 1 g

Supplier: Bioss

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Supplier: Bioss

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Supplier: Bioss

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.