"2-Amino-4,6-dichlorophenol"

Supplier: Apollo Scientific

PF-04620110

Supplier: Thermo Fisher Scientific

Neutral red ACS

Supplier: ProSci Inc.

Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.

Supplier: Apollo Scientific

Adenosine-5-Monophosphoric acid

Supplier: US Biological

Anti-GRIK3 Goat Polyclonal Antibody

Supplier: TCI

3-(Difluoromethoxy)aniline ≥98.0% (by GC, titration analysis)

Supplier: LGC Standards PROMOCHEM

2,3,3',5,5',6-Hexachlorobiphenyl (PCB No. 165)

Supplier: TCI

Xylenol orange disodium salt

Supplier: Apollo Scientific

Usage: Fluorinated building block/ reagent.

Supplier: Thermo Fisher Scientific

2-Aminopyrimidine 98%

Supplier: Bioss

The GCLC gene consists of 16 exons and encodes the 636 amino acid protein g-GCSc (g-glutamylcysteine synthetase heavy subunit), also designated g-L-glutamate-L-cysteine ligase catalytic subunit (GLCLC). g-GCSc is expressed in hemocytes, brain, liver and kidney. g-GCSc associates with a regulatory or modifier subunit, g-GCSm (g-glutamylcysteine synthetase light subunit), to form a heterodimer, g-GCS. g-GCS is the first enzyme involved and the rate determining step in glutathione biosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of g-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of g-GCS. Chemopreventive compounds cause increased levels of g-GCSc in kidney tissues, which may protect against chemically induced carcinogenesis. A His370Leu amino acid change in g-GCSc causes deficiencies in activity which are responsible for hemolytic anemia and low red blood cell glutathione levels.Defects in GCLC are the cause of hemolytic anemia.

Supplier: Apollo Scientific

Fmoc-2,4-dichloro-L-phenylalanine

Supplier: Apollo Scientific

tert-Butyl (4-aminophenyl)carbamate

Supplier: USP

Pharmaceutical Analytical Impurities are released through a USP quality process designed to ensure identity and quality appropriate for analytical applications. These impurities are supported with a product information sheet for each batch.

Supplier: DIAGNOSTIC SYSTEMS DIASYS

Creatinine

Supplier: Apollo Scientific

L-Histidine monohydrochloride monohydrate