115967 Results for: "1-Isopropyl-2,5-dimethyl-1H-pyrrole-3-carbaldehyde"

Supplier: Spectrum Chemical

EDTA dipotassium salt dihydrate ≥99%, Reagent Grade

Supplier: KIMA SAS DI CHIARIN RENZO

The test tubes are made from Polyethylene terephthalate (PET). Resistant to mechanical stress, centrifugation, breakage during standard procedures of use and in case of accidental falls. PET is a transparent material which enables the visual inspection of the blood and other biological liquids collected. Labels are made from self-adhesive paper for specific medical use, size 40×20 mm, printed in three colours.

Supplier: STEMCELL TECHNOLOGIES

Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets in vivo (Bartley et al.; de Sauvage et al.; Foster et al.; Sohma et al.). TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock and Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets (Ng et al.).

Supplier: Thermo Fisher Scientific

Ammonium cerium(IV) sulphate dihydrate 95% ACS

Supplier: MACRON AVANTOR BRAND

Avantor excipients are used during the formulation process in a wide range of applications. Avantor provides high-purity and performance excipients that serve as fillers, binders, disintegrants, lubicants, flavors, emulsifiers and preservatives. All the products are cGMP produced and meet USP grade standards.

Supplier: MP Biomedicals

MP EcoChrom™ SILICA is used as a suspending and thickening agent in pharmaceutical.A silica-based aerogel was used in the Stardust spacecraft to collect extraterrestrial particles. Silica is also used in the extraction of DNA and RNA due to its ability to bind to the nucleic acids under the presence of chaotropes. As hydrophobic silica it is used as a defoamer component. In hydrated form, it is used in toothpaste as a hard abrasive to remove tooth plaque. SiO2 has a number of distinct crystalline forms (polymorphs) in addition to amorphous forms. In the majority of silicates, the Si atom shows tetrahedral coordination, with 4 oxygen atoms surrounding a central Si atom.

MP EcoChrom™ Silica, the chemical compound silicon dioxide, also known as silica (from the Latin silex), is an oxide of silicon with the chemical formula SiO2 with a mean pore size of 60Å and particles size of 200-500μm. MP silica are free of particles outside the standard range. The irregular shape of MP Silica permits the easy packing of column permeability and plate number. They allow easy switching from one sieve cut to another, offering an easy way to change the chromatographic methods. It has been known for its hardness since ancient times. Silica is most commonly found in nature as sand or quartz, as well as in the cell walls of diatoms.

Supplier: ANTIBODIES.COM

Mouse Activated Protein C ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Activated Protein C in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: MP Biomedicals

Poly-lysine is a polycation which binds to DNA, red cell membrane and any negatively charged protein. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding. A compromise between the easier to use lower molecular weight products and the extremely viscous higher molecular weights would be the products in the range of 70,000-150,000.
It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Both the D- and L- form of the poly-lysine can be used as a coating substrate since poly-lysine is a nonspecific attachment factor for cells; however, certain cells can digest poly-lysine. In this case, poly-D-lysine should be used as the attachment factor so that the cells are not disrupted by excessive uptake of L-lysine.
Other uses for poly-lysine have been reported as well:
• Conjugation to methotrexate for increased drug transport.
• Microencapsulation of islets.
• Use in simple reproducible procedure for chromosomal preparations from a variety of tissues.
• Immobilation of living cells in biocompatible semipermeable microcapsules.
• In the preparation of polycationic beads.
• Conjugation to albumin and horseradish peroxidase to enhance cellular uptake.
Poly-D-lysine hydrobromide is a synthetic amino acid that enhances cell adhesion to solid substrates. It has additionally been shown to eliminate prion proteins from infected cells.

Supplier: AGILENT

High efficiency competent cells in convenient packaging designed to satisfy higher throughput requirements.

Supplier: Avantor Fluid Handling

Versatile pumps for accurate fluid delivery – with an intuitive touch-screen interface.

Supplier: PanReac AppliChem

EDTA disodium salt dihydrate 99.0-101.0% (by complexometric analysis) BP, Ph. Eur., USP, pharma grade

Supplier: STEMCELL TECHNOLOGIES

Macrophage colony-stimulating factor (M-CSF) is a homodimeric cytokine that belongs to receptor tyrosine kinase subclass III of the receptor tyrosine kinase (RTK) family. M-CSF acts on a CSF-1 receptor tyrosine kinase, which initiates signaling cascades to support cell proliferation and differentiation (Hamilton). M-CSF is produced by endothelial cells, osteoblasts, and during pregnancy by the uterine epithelial cells (Ryan). M-CSF synergizes with other factors to support proliferation and differentiation of multipotent hematopoietic progenitor cells, and regulates proliferation and differentiation of the mononuclear phagocyte progenitor cells to monocytes and macrophages. It also supports survival, proliferation, and function of the differentiated macrophages and regulates differentiation of mononuclear phagocytes to osteoclasts (Pixley and Stanley). M-CSF plays an important role in the implantation of the embryo and early development (Makrigiannakis et al.).

Supplier: Thermo Fisher Scientific

Ammonium iron(III) sulphate dodecahydrate 98.5-102.0% ACS

Supplier: STEMCELL TECHNOLOGIES

Fibroblast growth factor 4 (FGF-4) is a member of the FGF superfamily (Beenken and Mohammadi). FGF-4 is expressed in pluripotent stem cells and is implicated in various stages of development and morphogenesis in a variety of organisms (Kosaka et al. 2009). FGF-4 has been shown to have an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain (Kosaka et al. 2006). FGF-4 has also been shown to increase the proliferation rate of mesenchymal stem cells (Farré et al.). FGF-4 supports the maintenance and self-renewal properties of human embryonic stem cells and also promotes the proliferation of these cells (Mayshar et al.). In the mouse, the Fgf4 gene also supports proliferation of the inner cell mass (ICM) and postimplantation embryos (Feldman et al.).

Supplier: MP Biomedicals

Storage: Store at +4 °C, store under nitrogen
Glutathione is the major low molecular weight thiol compound of the living plant or animal cell. It is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. The sulfhydryl (thiol) group (SH) of cysteine serves as a proton donor and is responsible for the biological activity of glutathione.
Glutathione suppresses human immunodeficiency virus expression in chronically infected monocytic cells. It is a useful tripeptide involved in many aspects of metabolism, including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds.
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Supplier: ProSci Inc.

Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis , multiple sclerosis , and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al and Lee, et al. and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-κB pathway and like IL-17 also induces production of IL-8. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Studies have shown that IL17E binds strongly to IL17RB. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Exposure of mice to IL17 resulted in a Th-2 like response characterized by increased serum IgE, IgG1 and IgA levels, blood eosinophilia, increased lymphocytes and neutrophils, and pathological changes in the tissues that included eosinophilic infiltrates, increased mucus production, B-lymphocyte hyperplasia and epithelial cell hyperplasia/hypertrophy.

Supplier: Avantor

The USP/NF Offical Compendia of Standards contains a section titled, "Reagents, Indicators, and Solutions" that lists the quality requirements of chemicals to be used in compendia testing. PharmaTest reagents are tested according to these requirements, relieving you of the need to do additional testing on your reagents. Products may be reagent or other grade, but are labeled as "Meets reagent specifications for testing USP/NF monographs." Test solutions are labeled as PharmaTest.

Supplier: MERCK PRODUCTION CHEMICALS

L(+)-Lysine monohydrochloride, EMPROVE® EXPERT Ph. Eur., BP, USP suitable for use as excipient, SAFC®

Supplier: MP Biomedicals

p nitrophenol is the substrate of choice for use with alkaline phosphatase in ELISA procedures. This substrate produces a soluble end product that is yellow in color and can be read spectrophotometrically at 405 nm. The pNPP reaction may be stopped with 3 M NaOH and read at 405 nm.

Supplier: STEMCELL TECHNOLOGIES

Monokine induced by interferon-gamma (MIG), or CXCL9, is a member of the CXC chemokine family. MIG is closely related to two other chemokines: CXCL10 and CXCL11, all of which signal through the CXCR3 receptor (Ding et al.). MIG is secreted by a variety of immune cells including T cells, NK cells, dendritic cells, macrophages, and eosinophils, as well as non-immune cells including hepatic stellate cells, preadipocytes, thyrocytes, endothelial cells, tumor cells, fibroblasts, and glial cells of the central nervous system. MIG has also been shown to act as a chemoattractant for activated T cells and for tumor-infiltrating leukocytes (TILs), but not for neutrophils or for monocytes. MIG has also been reported to be both a tumor suppressor and tumor promoter in various types of cancer.

Supplier: EPPENDORF

Eppendorf twin.tec® real-time PCR plates, designed for low-volume qPCR, utilise white wells to enhance fluorescent light reflection, improving sensitivity and reproducibility in assays for reliable results.

Supplier: Thermo Fisher Scientific

EDTA disodium salt dihydrate 99+% ACS

Supplier: Honeywell Chemicals

EDTA disodium salt dihydrate 99-101% (by HPLC) Reag. Ph. Eur. for complexometry (NTA ≤0.1%), Fluka™

Supplier: STEMCELL TECHNOLOGIES

Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.).

Supplier: Thermo Fisher Scientific

EDTA disodium salt dihydrate 99+% for molecular biology DNase-, RNase-, protease-free

Supplier: MERCK PRODUCTION CHEMICALS

Titriplex® III (ethylenedinitrilotetraacetic acid disodium salt dihydrate), EMPROVE® ESSENTIAL Ph. Eur., BP, USP, JP, SAFC®

Supplier: Diversey

Solo is a hard water tolerant, low foaming, low freezing point liquid caustic detergent for dairy heat treated surface CIP applications. Solo is used for single stage CIP recovery cleaning in a wide range of applications, including cold surfaces as well. Solo can be used to clean a wide range of applications in dairy, e.g. HTST, homogenisers, storage, mixing and ageing tanks used in ice cream manufacture. Solo can be used to clean a wide range of applications across the food and beverage industries, e.g. vegetable evaporators in processed foods plants.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ‒40 °C ultra-low temperature freezers, powered by H-drive, feature three upright models, maximizing storage capacity from 40000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every laboratory.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ultra-low temperature freezers, powered by H-drive, feature four upright models with 5 Inner doors, maximizing storage capacity from 30000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every lab. Sustainability features include natural refrigerants and water-blown foam, compliant with many sustainability standards.

Supplier: VELP SCIENTIFIC

Premium digital homogeniser with advanced safety featuring a powerful brushless motor, electronic speed control, integral timer and counter function. Engineered for homogenisation, emulsification, suspensions, and high-speed mixing of cosmetic, food, and pharmaceutical products, as well as biological tissues.