Cyclodextrin phases for GC enantiomer separation.

LIPODEX® A is recommended for carbohydrates, polyols, diols, hydroxycarboxylic acid esters, (epoxy‑) alcohols, glycerol derivatives, spiroacetals, ketones, alkyl halides.
Phase: Hexakis-(2,3,6-tri-O-pentyl)-α-cyclodextrin

LIPODEX® B is ideal for lactones, diols (cyclic carbonates), aminols, aldols (O-TFA), glycerol derivatives (cyclic carbonates).
Phase: Hexakis-(2,6-di-O-pentyl-3-O-acetyl)-α-cyclodextrin

LIPODEX® C is recommended for alcohols, cyanhydrins, olefins, hydroxycarboxylic acid esters, alkyl halides.
Phase: Heptakis-(2,3,6-tri-O-pentyl)-β-cyclodextrin

LIPODEX® D is recommended for amines (TFA), aminols (TFA), trans-cycloalkane-1,2-diols, trans-cycloalkane-1,3-diols (TFA), β-amino acid esters.
Phase: Heptakis-(2,6-di-O-pentyl-3-O-acetyl)-β-cyclodextrin

LIPODEX® E is ideal for α-amino acids, α- and β-hydroxycarboxylic acid esters, alcohols (TFA), diols (TFA), ketones, pheromones (cyclic acetals), amines, alkyl halides, lactones.
Phase: Octakis-(2,6-di-O-pentyl-3-O-butyryl)-γ-cyclodextrin

LIPODEX® G is recommended for menthol isomers, ketones, alcohols, carboxylic acid esters, terpenes.
Phase: Octakis-(2,3-di-O-pentyl-6-O-methyl)-γ-cyclodextrin

Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C.

A large number of separations have been achieved and published in the literature. However, it is not possible to make a general prediction, which phase could solve a given separation task.