Specifications
- Pack type:Vial
- Pk:1 KIT
- Conjugation:Unconjugated
- Protein function:Cytokine
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Seq:0075
- Storage conditions:At or below −20 °C
- Biological activity:Bioactivity: No biological activity data is available at this time
- Endotoxin-free:N
- Carrier-free:Y
- Protease-free:N
- Animal-free:N
- Endotoxin level:Low
- Nuclease-free:N
- Grade:RUO
- Shipping temperature:RT
Specifications
About this item
Cytokines for polarizing human T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body. Disruption of the regular function or balance of Th17 cells is thought to be involved in several autoimmune diseases and/or opportunistic infections.
- High quality
- Low endotoxin
- Affordable
Th17 cells are characterized by their ability to produce IL-17, IL-22 and IL-21. Th17 cells can be cultured from naive CD4+ T cells by culturing them in the presence of anti-CD3 and anti-CD28 stimulation with recombinant IL-6 and recombinant TGF-β 1. In some cases neutralizing antibodies against IL-12, IL-4 and IFNγ are used along with recombinat cytokines IL-1 β, IL-21 and/or IL-23.