Specifications
- Antibody type:Primary
- Antigen name:programmed cell death 1
- Antigen symbol:Pdcd1
- Clonality:Monoclonal
- Clone:J43.1
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Host:Hamster
- Isotype:IgG
- Cross adsorption:No
- Form:liquid
- Gene ID:Q02242
- Antigen synonyms:Pdcd1
- Storage buffer:Phosphate-buffered aqueous solution, ≤0,09% Sodium azide, may contain carrier protein/stabiliser, ph 7,2.
- Storage temperature:The product should be stored undiluted at 4 °C and should be protected from prolonged exposure to light. Do not freeze.
- Shipping temperature:4 °C
- Purification:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Pk:0,025 mg
Specifications
About this item
The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50 to 55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.
Type: Primary
Antigen: Pdcd1
Clonality: Monoclonal
Clone: J43.1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Hamster
Isotype: IgG
Reactivity: Mouse