- Antibody type:Primary
- Antigen name:selectin, lymphocyte
- Antigen symbol:Sell
- Clonality:Monoclonal
- Clone:MEL-14
- Conjugation:PE (Phycoerythrin)-Cy7®
- Flow cytometry:Yes
- Host:Rat
- Isotype:IgG2a kappa
- Reactivity:Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:P18337
- Antigen synonyms:Sell
- Storage buffer:Phosphate-buffered aqueous solution, ≤0,09% Sodium azide, may contain carrier protein/stabiliser, ph 7,2.
- Storage temperature:The product should be stored undiluted at 4 °C and should be protected from prolonged exposure to light. Do not freeze.
- Shipping temperature:4 °C
- Purification:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Pk:0,025 mg
The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin: 74 kDa (on lymphocytes) or 95 kDa (on neutrophils).In the Mouseorganism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes.
Type: Primary
Antigen: Sell
Clonality: Monoclonal
Clone: MEL-14
Conjugation: PE (Phycoerythrin)-Cy7®
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse