SurePac™ Bio 550 SEC MDi™ columns and guards are based on high-purity, spherical, porous (550 Å) monodispersed silica particles that are covalently modified with a proprietary diol hydrophilic layer.

• Ideal for AAV gene therapy characterisation and quality control assessment due to selectivity of the dedicated smaller particle (3 µm) combined with wide-pore (550 Å) size
• Superior column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing
• High-efficiency peaks with excellent recovery
• Higher resolution and throughput for fast turnaround time without sacrificing performance
• Bioinert hardware to eliminate analyte absorption

This unique design yields shorter diffusion distances and enhanced reproducible mass transfer and narrower peaks. The consistent size of these particles facilitates precise control over media synthesis and column packing, significantly improving column-to-column and lot-to-lot reproducibility. The columns are housed in a hydrophilic bioinert-coated stainless-steel hardware to eliminate secondary interactions, ensuring optimal performance during the initial injection process.