- Antibody type:Primary
- Antigen name:5HT2B Receptor/SR-2B
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Epitope:1-100/481
- Form:Liquid
- Antigen synonyms:5 hydroxytryptamine serotonin receptor 2B G protein coupled|5-hydroxytryptamine receptor 2B|SEROTONIN 5HT2B RECEPTOR|5-HT2B|5-HT-2B|Htr2b|Serotonin receptor 2B|5HT2B_HUMAN|5HT2B|5 HT2B|NP75 protein|5HT2F|5 hydroxytryptamine receptor 2B|5 hydroxytryptamine 2B receptor|Htr 2b|5 HT 2B|Stomach fundus serotonin receptor|5 hydroxytryptamine serotonin receptor 2B|5 HT 2B receptor
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:54 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human 5HT2B Receptor/SR-2B
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
Type: Primary
Antigen: 5HT2B Receptor/SR-2B
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 1-100/481
Host: Rabbit
Isotype: IgG
Reactivity: Human