Specifications
- Antibody type:Primary
- Antigen name:EXTL3
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat
- Western blot:Yes
- Epitope:351-450/919
- Form:Liquid
- Gene ID:2137
- Antigen synonyms:REGR|EXTR1|Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas|botv|RPR|EXTL3_HUMAN|Multiple exostosis-like protein 3|Putative tumor suppressor protein EXTL3|Exostoses multiple-like 3|EXTL1L|Hereditary multiple exostoses gene isolog|KIAA0519|Exostosin-like 3|Exostoses-like 3|EXT-related protein 1|Reg receptor|DKFZp686C2342|EXTL3|REG|Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol.
- Molecular weight:105 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human EXTL3
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.
Type: Primary
Antigen: EXTL3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 351-450/919
Host: Rabbit
Isotype: IgG
Reactivity: Rat