HiScreen™ columns prepacked with Capto Core 400 are designed for intermediate purification and polishing of viruses and other large biomolecules. Novel core bead technology and multimodal ligand give Capto Core 400 dual functionality, size exclusion and binding chromatography, in one chromatography resin.

• For intermediate purification and polishing of viruses and other large biomolecules (Mr >350000) in flowthrough mode
• Novel core bead technology allows efficient capture of contaminants, while target molecule is collected in the flowthrough
• Significantly improved productivity and higher flow rates compared with gel filtration methods
• Straightforward optimisation due to flowthrough chromatography and robust performance
• Convenient small-scale purification, process development, and scale-up using prepacked HiTrap™ and HiScreen™ columns

Capto Core 400 is an excellent alternative to size‑exclusion chromatography (SEC) resins that are typically employed in the final stages of virus purification in vaccine manufacture.