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Anti-c-FOS Mouse Monoclonal Antibody
Anti-c-FOS Mouse Monoclonal Antibody
  BSENM-1752-100
 :  Biosensis
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Anti-c-FOS Mouse Monoclonal Antibody
  BSENM-1752-100
 :  Biosensis

 

  • Antibody type:
    Primary
  • Antigen name:
    Cellular oncogene fos
  • Antigen symbol:
    c-FOS
  • Clonality:
    Monoclonal
  • Conjugation:
    Unconjugated
  • Host:
    Mouse
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG1
  • Reactivity:
    Pig,
    Horse,
    Chicken,
    Human,
    Bovine,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Form:
    Lyophilised
  • Gene ID:
    P01100 FOS_HUMAN
  • Antigen synonyms:
    cFOS|G0/G1 switch regulatory protein 7
  • Storage buffer:
    PBS, pH 7,4, with 3% Trehalose, without preservatives
  • Storage temperature:
    2 to 8 °C
  • Shipping temperature:
    Room (ambient) temperature
  • Immunogen:
    Full length, E.coli-derived recombinant human c-FOS protein
  • Purification:
    Affinity purified
  • Size:
    100 µg
  • Pk:
    100 µG

 

 

This antibody is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.

  • Has a critical function in regulating the development of cells
  • Has a important role in signal transduction, cell proliferation and differentiation

C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.

Concentration range for immunohistochemistry (IHC) and immunocytochemistry (ICC) is 1 to 2 µg/ml and for western blotting (WB) is 0,5 to 1,0 µg/ml. This antibody works on 4% PFA fixed mouse brain sections and detects bands between 50 to 65 kDa, which only appear in stimulated cells.

This antibody can be reconstituted with 100 µl sterile-filtered, ultrapure water, to achieve an antibody concentration of 1 mg/ml.
Store lyophilised, unopened vial at 2 to 8 °C or lower. After reconstitution, prepare aliquots and store at ‒20 °C for a higher stability. Avoid freeze-thaw cycles.

Type: Primary
Antigen: c-FOS
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Chicken, Cow, Horse, Human, Mouse, Pig, Rat