Angiotensin II plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland.

Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125^FAK and a cytosolic 115 to 120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60^c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.