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PD 158780
Supplier: Abcam
Potent ErbB receptor tyrosine kinase inhibitor (IC₅₀ values are 8 μM, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively). Does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G₁ cell cycle arrest and shows antiproliferative effects in vitro. Active in vivo. Centrally active.
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