Specifications
- Antibody type:Primary
- Antigen name:CNOT2 Ser101
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:Liquid
- Gene ID:4848
- Antigen synonyms:NOT2 negative regulator of transcription 2 yeast homolog|HSPC131|CCR4-associated factor 2|p-CNOT2Ser101|Negative regulator of transcription 2|CCR4 associated factor 2|CCR4 NOT transcription complex subunit 2|CDC36|CNOT2 phospho S101|CNOT2|MSTP046|CNOT2_HUMAN|NOT2H|CCR4-NOT transcription complex subunit 2|NOT2
- Modification:Phosphorylation (Ser101)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human CNOT2 around the phosphorylation site of Ser101
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
CNOT2 (CCR4-NOT transcription complex subunit 2) is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family and is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT2) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase (HDAC) inhibitor trichostatin A.
Type: Primary
Antigen: CNOT2 Ser101
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat