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Anti-DR1 protein Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Anti-DR1 protein Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-9055R-A680
Supplier:  Bioss
Anti-DR1 protein Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-9055R-A680
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    DR1 protein
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 680
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Epitope:
    51-150/176
  • Form:
    Liquid
  • Gene ID:
    10589
  • Antigen synonyms:
    Down regulator of transcription 1|Protein Dr1|NC2-beta|NC 2|NC2|Dr1 protein|Negative cofactor 2-beta|Negative co factor 2|Negative cofactor 2|Negative cofactor 2 beta|Dr1|TATA binding protein associated phosphoprotein|Down-regulator of transcription 1|NC2B_HUMAN|DR 1|TATA-binding protein-associated phosphoprotein|Down regulator of transcription 1 TBP binding|NC2 beta
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human DR1 protein
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localises to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.

Type: Primary
Antigen: DR1 protein
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 51-150/176
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat