Specifications
- Antibody type:Primary
- Antigen name:UPF1 Regulator of nonsense transcripts homolog
- Antigen symbol:UPF1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Gene ID:5976
- Antigen synonyms:KIAA0221 |NORF1|EC 3.6.1.- |FLJ46894|pNORF1|FLJ43809 |HUPF1|hUpf1 |RENT1
- Storage buffer:Aqueous buffered solution containing 100 μg/ml BSA, 50% glycerol and 0,09% sodium azide. Store at −20 °C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4 °C
- Purification:Purified by Protein A
- Size:100 μg
- Pk:100 µl
Specifications
About this item
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
Recommended Dilutions: Western Blot: 1:100 to 1000; IHC-P: 1:100 to 500; IF(IHC-P): 1:50 to 200.
Type: Primary
Antigen: UPF1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat