Specifications
- Vasta-aineen tyyppi:Ensisijainen
- Antigeenin nimi:Allergin-1
- Klonaalisuus:Polyclonal
- Konjugaatio:Alexa Fluor® 750
- Isäntä:Rabbit
- ImmunoKemia:Yes
- ImmunoFluoresenssi:Yes
- Isotyyppi:IgG
- Epitooppi:61-160/343
- Lomake:Liquid
- Antigeenin synonyymit:C17orf60|Chromosome 17 open reading frame 60
- Modification:Unmodified
- Säilytyspuskuri:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekyylipaino:36 kDa
- Säilytyslämpötila:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Pitoisuus:1 µg/µl
- Kuljetuslämpötila:4 °C
- Immunogeeni:KLH conjugated synthetic peptide derived from human Allergin-1
- Testatut aplikaatiot:ICC
- Puhdistus:Purified by Protein A
- Pakkaustyyppi:Vial
- Pak.:100 µl
Specifications
About this item
As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.
Type: Primary
Antigen: Allergin-1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 61-160/343
Host: Rabbit
Isotype: IgG
Reactivity:
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: VWR Chemicals
Supplier: HEATHROW
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: KIMBERLY CLARK
Supplier: VWR Chemicals
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: Merck