- Antibody type:Primary
- Antigen name:Inositol Polyphosphate-5-Phosphatase D
- Antigen symbol:INPP5D
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 555
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:3635
- Antigen synonyms:SH2 domain-containing inositol-5'-phosphatase 1|hp51CN|Inositol polyphosphate-5-phosphatase of 145 kDa|SHIP|p150Ship|Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1|INPP5D|SHIP1|SHIP-1|SH2 domain-containing inositol phosphatase 1|SIP-145
- Modification:phospho-Tyr1020
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: INPP5D
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat