Specifications
- Antibody type:Primary
- Antigen name:Kir6.2 (KCNJ11)
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:301-390/390
- Form:Liquid
- Gene ID:3767
- Antigen synonyms:KCNJ11|TNDM 3|IRK11_HUMAN|Potassium inwardly rectying channel J11|IRK11|IKATP|Kir 6.2|Potassium channel, inwardly rectying subfamily J member 11|TNDM3|HHF 2|ATP sensitive inward rectier potassium channel 11|BIR|Kir6.2|MGC133230|Inwardly rectying potassium channel KIR6.2|IRK 11|HHF2|Beta cell inward rectier subunit|mBIR|Inward rectier K+ channel Kir6.2|PHHI
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:43 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Kir62
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterised by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Type: Primary
Antigen: Kir6.2 (KCNJ11)
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-390/390
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat