- Antibody type:Primary
- Antigen name:HGD
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western blot:Yes
- Epitope:351-445/445
- Form:Liquid
- Gene ID:3081
- Antigen synonyms:Homogentisicase|HGD_HUMAN|Homogentisate oxidase|Homogentisate oxygenase|AKU|2-dioxygenase|HGO|Homogentisate 1|FLJ94126|Homogentisate 1 2 dioxygenase|hgd|Homogentisic acid oxidase
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:50 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human HGD
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
HGD is a 445 amino acid protein that belongs to the homogentisate dioxygenase family and is involved in the pathway of amino acid degradation. Expressed at high levels in kidney, colon, liver, prostate and small intestine, HGD uses iron as a cofactor to catalyse the oxygen-dependent conversion of homogentisate to 4-maleylacetoacetate, a reaction that is the fourth step in the creation of L-phenylalanine from fumarate and acetoacetic acid. Defects in the gene encoding HGD are the cause of alkaptonuria (AKU), an autosomal recessive disorder that is characterised by urine that turns dark on standing and alkalinisation, black ochronotic pigmentation of cartilage and collagenous tissues and spine arthritis.
Type: Primary
Antigen: HGD
Clonality: Polyclonal
Clone:
Conjugation: Cy3
Public Immunogen Range: 351-445/445
Host: Rabbit
Isotype: IgG
Reactivity: Mouse