Anti-CSTF3 Rabbit Polyclonal Antibody

Catalog # BOSSBS-12935R

Supplier: Bioss

Catalog # BOSSBS-12935R

Supplier: Bioss

Specifications

Vasta-aineen tyyppi:
Ensisijainen
Antigeenin nimi:
Cleavage Stimulation Factor, 3' pre-RNA, Subunit 3, 77kDa
Antigeenin symboli:
CSTF3
Klonaalisuus:
Polyclonal
Konjugaatio:
Unconjugated
Isäntä:
Rabbit
ImmunoKemia:
Yes
Isotyyppi:
IgG
Reaktiivisuus:
Human,
Rat,
Mouse
Western blot:
Yes
Lomake:
liquid
Geeni ID:
1479
Antigeenin synonyymit:
MGC75122|CSTF 77 kDa subunit|MGC117398|cleavage stimulation factor 3' pre-RNA subunit 3 77kDa|cleavage stimulation factor subunit 3 isoform 1|cleavage stimulation factor subunit 3|MGC43001|CSTF-77
Säilytyspuskuri:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
Pitoisuus:
1 ug/ul
Kuljetuslämpötila:
4 °C
Puhdistus:
Purified by Protein A.
Pistosyvyys:
100 μg
Pak.:
100 µl

Specifications

About this item

Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. Heterotrimeric CstF recognizes GU- and U-rich sequences located downstream of the polyadenylation site on RNA. CstF-77 (cleavage stimulation factor, 77 kDa subunit), also known as CstF3, is one of the three subunits comprising CstF. It can exist as a homodimer and functions as the bridge, directly interacting with the other two CstF subunits, namely CstF-64 and CstF-50. CstF-77 is highly conserved among eukaryotes. It contains an Alpha-helical structure with 11 HAT (Half-a-TPR-containing) repeats and is essential for CstF assembly. In addition, CstF-77 is capable of interacting with CPSF1 and FCP1, other factors involved in polyadenylation.

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Type: Primary
Antigen: CSTF3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: