- Antibody type:Primary
- Antigen name:SET Domain, Bifurcated 1
- Antigen symbol:SETDB1
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Similar to DNA topoisomerase II.|H3 lysine 9 specic 4|ESET|Histone lysine N methyltransferase|KMT1E|SETB1_HUMAN|SETB|MGC90670|ERG-associated protein with SET domain|Histone-lysine N-methyltransferase SETDB1|Set domain protein|KIAA0067|Lysine N-methyltransferase 1E|Histone H3-K9 methyltransferase 4|Histone H3 K9 methyltransferase 4|SET domain burcated 1|KIAA00067|H3 K9 HMTase 4|mKIAA0067|KG1T|1|SETDB1|burcated|H3-K9-HMTase 4|H3-K9-HMTase4
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
ESET is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SETDB1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat