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Anti-IKK alpha / beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Anti-IKK alpha / beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-10123R-A680
Supplier:  Bioss
Anti-IKK alpha / beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Catalog # BOSSBS-10123R-A680
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    IKK alpha / beta
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 680
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Mouse
  • Western blot:
    Yes
  • Epitope:
    151-250/756
  • Form:
    Liquid
  • Antigen synonyms:
    IKK _|IKK B|MGC131801|IKK beta|IKK-Alpha|Inhibitor of nuclear factor kappa B kinase subunit beta|IkBKB|IKK 2|IKKB|Nuclear factor of kappa light chain gene enhancer in B cells inhibitor|IKK_|Nuclear factor NF kappa B inhibitor kinase beta|IKK 1|IKK Alpha|I kappa A kinase 2|Inhibitor of kappa light chain gene enhancer in B cells|IKK1|IKK2|IKK A|IKKA|Inhibitor of kappa light polypeptide gene enhancer in B cells|IKK-_|NFKBIKB|I kappa B kinase beta|I kappa B kinase 2|I kappa A kinase Alpha|Inhibitor of nuclear factor kappa B kinase beta subunit|Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta|IkBKA
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    83 kDa
  • Storage temperature:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human IKK Alpha/IKK beta
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

Type: Primary
Antigen: IKK alpha / beta
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 151-250/756
Host: Rabbit
Isotype: IgG
Reactivity: Mouse